JOHANNESBURG (Reuters) - South Africa's benchmark index ended slightly lower on Tuesday as a pull-back in some of the strongest performers this year cancelled out a rebound in recently beaten-down mining shares.
Investors also refrained from making aggressive bets at the start of the U.S. earnings season.
The blue-chip JSE Top-40 index inched down 0.16 percent to 33,930.95 points after setting a 2013 low of 33,774.82 during the session. The wider JSE All-share index edged down 0.11 percent to 38,540.81.
"We are seeing a bit of a sell-off on some of the shares that have actually been holding up nicely this year," said Ferdi Heyneke, a portfolio manager at Afrifocus Securities.
"At the same time, some can see value in mining shares because they have been hit quite a lot this year."
Global brewer SABMiller, one of the four best-performing stocks on the benchmark index this year, lost 2.5 percent.
Private hospital group Mediclinic retreated 1.87 percent to 63 rand, paring this year's gains to just under 15 percent.
Mining shares restricted the downside momentum, boosted by higher commodity prices and Chinese data suggesting sustained demand from the world's biggest consumer of industrial metals.
Base metals producer Assore, the second-worst blue chip performer this year, jumped 7.03 percent to 293 rand.
Gold Fields, the worst blue chip performer year-to-date with a near one-third drop, climbed 5.28 percent to 67.61 rand.
Elsewhere, Tsogo Sun surged 6.08 percent to 25.99 rand after the hotel and casino operator said it would invest $83 million expanding its two flagship casinos.
TORONTO (AP) -- The maker of the BlackBerry phone said Tuesday that a modern smartphone with a physical keyboard will be available in Canada in the coming weeks as major wireless companies started taking advance orders.
Details on when the BlackBerry Q10 will go on sale elsewhere will be announced soon, Research In Motion Ltd. said. Advance orders are already being accepted in the U.K.
The BlackBerry, pioneered in 1999, had been the dominant smartphone for on-the-go business people and other consumers before the iPhone debuted in 2007 and showed that phones can handle much more than email and phone calls. RIM faced numerous delays modernizing its operating system with the BlackBerry 10. During that time, it had to cut more than 5,000 jobs and saw shareholder wealth decline by more than $70 billion.
RIM surprised Wall Street last month by returning to profitability and shipping about 1 million touch-screen BlackBerry Z10 phones in the most recent quarter, which ended March 2. It will take several quarters, though, to know whether RIM is on a path toward a successful turnaround. RIM had just entered the critical U.S. market with the Z10 phone, and the more anticipated Q10 keyboard phone won't be on sale until late May or June because of testing by U.S. wireless companies.
The U.S. delay in selling the new keyboard BlackBerry complicates RIM's efforts to hang on to customers tempted by Apple's iPhone and a range of devices running Google Inc.'s Android operating system. Even as the BlackBerry has fallen behind rivals in recent years, many BlackBerry users have stayed loyal because they prefer a physical keyboard over the touch screen found on the iPhone and most Android devices. The temptations to switch grow with each additional delay, despite favorable reviews for BlackBerry 10 operating system.
Canadian carriers Rogers Communications Inc. and Telus Corp. both said Tuesday that advance orders are under way for the keyboard Q10 device, but neither would provide an exact date for when the Q10 would be available. Telus is offering the phone one a $199 with a three-year service agreement or $700 without a contract.
The all-touch-screen Z10 launched in Canada and other markets earlier this year and in the United States last month.
Powerball, the?ubiquitous?lottery game, finally arrived in California on Monday, and began to spread its enticing message of easy, instant fortune to residents of the Golden State. That message appears to have been a success: According to a press release distributed by California's lottery authority, more than 700,000 Californians purchased Powerball tickets in the 24 hours since they went on sale, generating approximately $3.1 million dollars in revenue for the Multi-State Lottery Association, the non-profit outfit which administers lotteries in 33 states. ...
Well, we switched internet services, and I hoped that would give me a stable enough online connection that I could join the wonders of gaming online.
After a promising start, the company ?fixed? our service. Now my computer is like a wet log, sluggishly surfacing to connect and then lolling over under the surface again. The connection is not better than it was before. Maybe we can do something with it, maybe not, but the short version is, no online gaming for Andrew.
Which makes me all the more appreciative of my local game group.
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KANDAHAR, Afghanistan (Reuters) - Six foreigners and an Afghan were killed in two separate attacks in Afghanistan on Saturday, local and international officials said.
Six people, including three NATO soldiers, died in a car bomb attack on a convoy of vehicles in Zabul province's capital, Qalat. Provincial governor Mohammad Ashraf Nasery, travelling in the convoy, was unharmed but a local doctor was killed, as were three American soldiers and two foreign civilians, according to local and NATO officials.
The cars were en route to a school and were near to a hospital and a NATO base when the car bomb exploded.
Five Afghans, including a student and two reporters, were also wounded, a local official said.
In a separate attack in Afghanistan's east, a U.S. civilian working with the American government was killed during an insurgent attack, the NATO-led International Security Assistance Force (ISAF) said in a statement.
Zabul shares borders with Pakistan to the southeast and the birthplace of the Taliban, Kandahar province, to the south.
The Taliban claimed responsibility for the Zabul attack via a text message from spokesman Qari Yousuf Ahmadi. He said a car bomb killed seven foreigners and wounded five others, though he later revised the toll to 13 foreigners killed and nine wounded.
The Taliban routinely exaggerate casualty figures.
The killings come in the wake of a bloody Taliban assault in the country's west several days ago that killed 44 people. The United Nations says civilians are being increasingly targeted in 2013.
(Reporting by Ismail Sameem; Writing by Dylan Welch; Editing by Stephen Powell)
BOAO, China (Reuters) - The head of the International Monetary Fund hailed Japan's unprecedented monetary policy boost this week as a welcome support for a world economy that she said has improved from a year ago.
Christine Lagarde said on Sunday the radical $1.4 trillion stimulus from the Bank of Japan (BoJ) would help strengthen the advanced economies, saying growth in countries such as the United States was gaining speed.
But without referring specifically to Japan, Lagarde warned policymakers against thinking that super-loose monetary policy alone could do the heavy lifting in reviving economies, when growth may instead be stifled by unhealthy private and public finances.
"Monetary policies, including unconventional measures, have helped prop up the advanced economies, and in turn, global growth," Christine Lagarde told a forum in south China.
"The reforms just announced by the Bank of Japan are another welcome step in this direction," she said. "There is, however, a limit to how effectively monetary policy can continue to shoulder the lion's share of this effort."
Central banks still need to heed broken balance sheets that impede lending and plan for and guard against uncertainties arising from any policy change, the IMF chief said.
Japan stunned investors on Thursday by unleashing the world's most intense burst of monetary stimulus, which will pump $1.4 trillion into its economy in under two years. It hopes the shock therapy will end two decades of stagnation.
But the move is a huge gamble. It heavily exposes the BoJ to Japan's mountain of public debt and carries the potential for big losses if inflation spikes and investors lose faith in its viability.
Japan's government debt, at twice the size of its $5 trillion economy, is proportionally the highest among developed nations.
Lagarde said fiscal problems in developed nations such as Japan and the United States marred the global economic recovery and contrasted with emerging economies, where a broadening rebound is brightening the outlook.
ENVIABLE
Lagarde said the IMF expected Asian economies to grow by nearly 6 percent this year, "an enviable performance by any measure", as resilient domestic demand and accommodative policies power the region.
She said the impressive growth rate is customary for Asia, which has accounted for two-thirds of global growth in the last five years since the financial crisis struck.
Asia's buoyancy has rubbed off on the rest of the world.
"A substantial portion of the global economy looks better today than it did last year," Lagarde said. "And we are beginning to see momentum pick up in the United States."
In the euro zone, however, she said debt problems are weighing on growth and dragging out a recession.
Lagarde said the main task for the currency zone right now is to push for a banking union, a plan that is meant to put an end to the euro zone's debt troubles by severing the link between sovereign borrowers and banks.
Last month, however, Dutch Finance Minister Jeroen Dijsselbloem said European aid for troubled banks is a last resort, which raised doubts about the plan for a banking union.
Dijsselbloem made the comments after a rescue program was agreed for Cyprus that imposed steep losses on depositors, leading to suggestions that the Cypriot deal could serve as a precedent for future bank bailouts in the bloc.
Lagarde said Cyprus was not a model for the rest but that the pecking order for investors to absorb losses including depositors must be respected.
"When a financial institution goes under, a resolution process has to take place that will constantly be shouldered by taxpayers, either in the country or in the region or in the world," she said.
The rise of the "Internet of Things" promises to connect us wirelessly to all the gadgets around us, making our lives easier. That includes some surprising devices that are now networked.
By Rachel Rosmarin
", credit: "", sourceid: null, sourcename: "", sourceurl: null, sourcelogo: "", thumbsrc: "/cm/popularmechanics/images/jk/networked-devices-01-0413-smn.jpg", src: "/cm/popularmechanics/images/nN/networked-devices-01-0413-lgn.jpg", srcwidth: 600, srcheight: 450 }, { id: "slide2", url: "12-devices-you-didnt-know-were-web-connected-2", slidetype: "image", title: "Pet Feeder", description: "Working late? Feed Fido by tapping the screen on your iOS, Android, or Windows 8 app. The Wi-Fi-connected kibble receptacle can hold from 5 to 10 pounds of pet food, and dispense whatever amount you choose\n
\nUsers also can trust Pintofeed to know when their pet wants to eat based on when they\'ve eaten in the past. The device will come up with a feeding schedule and notify you via text, email, Facebook, or Twitter when each meal has been served. Pintofeed is heading into production now; you can reserve one for $129.", credit: "", sourceid: null, sourcename: "", sourceurl: null, sourcelogo: "", thumbsrc: "/cm/popularmechanics/images/wz/networked-devices-02-0413-smn.jpg", src: "/cm/popularmechanics/images/f2/networked-devices-02-0413-lgn.jpg", srcwidth: 600, srcheight: 450 }, { id: "slide3", url: "12-devices-you-didnt-know-were-web-connected-3", slidetype: "image", title: "Weather Cube", description: "A glance at your phone\'s weather app will reveal tomorrow\'s temperature. But it won\'t let you feel it. The thermoelectric element inside this Wi-Fi-connected metal cube can take it down to 0 degrees Fahrenheit or up to 100. Touching the temperature you\'ll be feeling tomorrow on the Cryoscope makes it real?you\'ll know for certain whether you need to take a sweater.", credit: "Robb Godshaw", sourceid: null, sourcename: "", sourceurl: null, sourcelogo: "", thumbsrc: "/cm/popularmechanics/images/fw/networked-devices-03-0413-smn.jpg", src: "/cm/popularmechanics/images/lg/networked-devices-03-0413-lgn.jpg", srcwidth: 600, srcheight: 450 }, { id: "slide4", url: "12-devices-you-didnt-know-were-web-connected-4", slidetype: "image", title: "Doorbell", description: "In the Harry Potter books, Mrs. Weasley owns a clock that tells her where her family members are. MIT Media Lab\'s Tangible Media Group envisions something similar: A doorbell that chimes a different sound when each member of the household is nearing home. It pulls data from each family member\'s Google Latitude account, a location-based mobile app that relies on Google Maps for GPS and cell-tower triangulation data. The doorbell alert means you won\'t have to stop cooking dinner when you want an update on your kids\' commute.", credit: "", sourceid: null, sourcename: "", sourceurl: null, sourcelogo: "", thumbsrc: "/cm/popularmechanics/images/0D/networked-devices-04-0413-smn.jpg", src: "/cm/popularmechanics/images/tn/networked-devices-04-0413-lgn.jpg", srcwidth: 600, srcheight: 450 }, { id: "slide5", url: "12-devices-you-didnt-know-were-web-connected-5", slidetype: "video", title: "Mirror", description: "Flat-panel displays are everywhere?even screens at gas stations and in elevators tell us the weather and the news. But this one by Cybertecture is also a Wi-Fi-connected mirror. Put it in the bathroom and it will relay health data, let you browse social networks, watch video, and even check your form while exercising. The mirror gleans health data from an optional peripheral: a sensor pad that functions as a scale that calculates body fat, muscle mass, and bone mass, in addition to weight.", credit: "", sourceid: null, sourcename: "", sourceurl: null, sourcelogo: "", thumbsrc: "/cm/popularmechanics/images/SW/networked-devices-05-0413-smn.jpg", videotype: "embedded" }, { id: "slide6", url: "12-devices-you-didnt-know-were-web-connected-6", slidetype: "video", title: "Piano", description: "\"Play it, @StanleyPiano. Play \'As Time Goes By.\'\"\n
\nSeattle agency Digital Kitchen created a player piano that receives tweets of song titles. It then takes MIDI files of those songs and turns them, via a USB interface, into ivory-tickled keynotes using a hardware controller. There\'s no satisfaction quite like commanding an old-school analog instrument to strike up a tune via your smartphone.", credit: "", sourceid: null, sourcename: "", sourceurl: null, sourcelogo: "", thumbsrc: "/cm/popularmechanics/images/F6/networked-devices-06-0413-smn.jpg", videotype: "embedded" }, { id: "slide7", url: "12-devices-you-didnt-know-were-web-connected-7", slidetype: "image", title: "Lightbulb", description: "Another Kickstarter success story, the energy-efficient Lifx bulb (available for preorder at $69 apiece) screws into existing sockets and is controlled via Wi-Fi on an iOS or Android app. You can tell it (or them, if you install multiple bulbs) to turn on and off at different times, dim and brighten slowly, change colors, flash in patterns, and more. The manufacturer also promises \"robot dancing.\" While the prospect of an Internet-enabled living-room rave sounds fun, the lazy comfort of dimming the lights from the couch or turning on the light in the basement before heading down the steps is even more appealing.", credit: "", sourceid: null, sourcename: "", sourceurl: null, sourcelogo: "", thumbsrc: "/cm/popularmechanics/images/kr/networked-devices-07-0413-smn.jpg", src: "/cm/popularmechanics/images/0m/networked-devices-07-0413-lgn.jpg", srcwidth: 600, srcheight: 450 }, { id: "slide8", url: "12-devices-you-didnt-know-were-web-connected-8", slidetype: "image", title: "Environmental Sensors", description: "In Star Trek, the Tricorder is the ultimate environmental sensor and data-analysis device. Curious earthbound types who\'ve wished for one may soon be able to play-act with the Sensordrone, a gadget with built-in sensors that sends data directly to smartphones in real time. The phones can then relay data to the Web via tweets and other social media. This is the Swiss Army Knife of data gathering.\n
\nSensors include temperature, humidity, light, IR barometer, blood alcohol level, carbon monoxide, and gas. Blood-pressure monitors are expected soon, but no word on whether a radiation detector is in the works. You can set your smartphone to automatically tweet data gathered from the sensors.", credit: "", sourceid: null, sourcename: "", sourceurl: null, sourcelogo: "", thumbsrc: "/cm/popularmechanics/images/nq/networked-devices-08-0413-smn.jpg", src: "/cm/popularmechanics/images/Hn/networked-devices-08-0413-lgn.jpg", srcwidth: 600, srcheight: 450 }, { id: "slide9", url: "12-devices-you-didnt-know-were-web-connected-9", slidetype: "image", title: "Gardening Assistant", description: "Attention hydroponic gardeners: Not sure about optimum light, water, and temperature levels for your plants? Sensors placed in your planters can measure water, temperature, humidity, brightness, pH, and nutrient concentration, and can help to yield a better crop. Bitponics\' gear, currently in development, takes measurements from the air and soil and uploads them automatically to a Web interface for analysis, helping to turn your black thumb to green.", credit: "", sourceid: null, sourcename: "", sourceurl: null, sourcelogo: "", thumbsrc: "/cm/popularmechanics/images/9D/networked-devices-09-0413-smn.jpg", src: "/cm/popularmechanics/images/TX/networked-devices-09-0413-lgn.jpg", srcwidth: 600, srcheight: 450 }, { id: "slide10", url: "12-devices-you-didnt-know-were-web-connected-10", slidetype: "image", title: "Paper-Craft Toys", description: "ReaDIYmates are pattern kits for paper-craft toys (monsters and sculptures). Each one comes with a paper body, a built-in motor and speaker, and a tiny processor with some flash memory and a Wi-Fi radio. Thanks to this hardware, you can turn these bits of paper and wire into amiable creatures by using your creative touch.\n
\nWith simple Web commands, for example, teach them to dance using your iPhone\'s accelerometer, tweet, or send voice memos. Have them holler and shimmy when someone likes your latest Facebook post. Or use these highly personalized toys to entertain someone, even from a Web browser half a world away.", credit: "", sourceid: null, sourcename: "", sourceurl: null, sourcelogo: "", thumbsrc: "/cm/popularmechanics/images/SI/networked-devices-10-0413-smn.jpg", src: "/cm/popularmechanics/images/f7/networked-devices-10-0413-lgn.jpg", srcwidth: 600, srcheight: 450 }, { id: "slide11", url: "12-devices-you-didnt-know-were-web-connected-11", slidetype: "image", title: "Music Box", description: "Miss the tactile feel of mix tapes, but don\'t want to store your music on flimsy disposable media? The Spotify box, a prototype built by designer Jordi Parra, appeals to nostalgic types who\'ve lamented the Internet-only aspect of modern music consumption but don\'t want to eschew the endless variety available online. Tiny RFID tokens link directly to Spotify music playlists or artist tags that play when you place them on the Web-connected box.", credit: "", sourceid: null, sourcename: "", sourceurl: null, sourcelogo: "", thumbsrc: "/cm/popularmechanics/images/d5/networked-devices-11-0413-smn.jpg", src: "/cm/popularmechanics/images/A0/networked-devices-11-0413-lgn.jpg", srcwidth: 600, srcheight: 450 }, { id: "slide12", url: "12-devices-you-didnt-know-were-web-connected-12", slidetype: "image", title: "Lamps", description: "The Good Night Lamp is a beautifully designed light fixture shaped like a house. It comes with a larger and smaller version of the same design. Turning on the big lamp at your home also turns on the little one, which might be in your daughter\'s dorm room. The two users decide what on and off mean; turning the light off could mean \"I\'m asleep,\" or turning it on could mean \"I have time to talk on the phone now.\"\n
\nSure, people could send these messages by text. But the Good Night Lamp\'s designers think of it as a way to feel the presence of someone located far away. The lamp failed to meet its Kickstarter goals, but its creators still plan to move forward with the project.", credit: "", sourceid: null, sourcename: "", sourceurl: null, sourcelogo: "", thumbsrc: "/cm/popularmechanics/images/sV/networked-devices-12-0413-smn.jpg", src: "/cm/popularmechanics/images/R0/networked-devices-12-0413-lgn.jpg", srcwidth: 600, srcheight: 450 } ] };
Air Quality Egg
Air-quality levels monitored and reported by the government don't take into account the conditions right outside your doorstep. If you knew that nitrogen dioxide and carbon monoxide levels in your neighborhood or near your child's school were especially high on any given day, you might choose to keep young lungs inside.
The Air Quality Egg gives you exactly this information. Sensors measure air quality outside your front door, and then an RF transmitter sends the data to an egg-shaped base station in your house. The Egg, which turns different colors to alert you to changes in the air quality, sends the data on to a service that graphs it for the public.
The collective information from Eggs around the world could ultimately help researchers studying the environmental causes for a variety of diseases, such as heart and lung disease.
The tale of Google and Frommer's famed travel guides has taken another twist this evening. Associated Press writer Beth Harpaz reports Arthur Frommer confirmed over the phone that he has retaken control of the brand from Google, and plans to continue publishing them in e-book and print formats, as well as maintaining the Frommers.com website. This comes after Google acquired the brand from publisher Wiley in 2012, followed by Skift.com's revelation last month that it apparently intended to shut production of the books down.
We're told by a Google spokesperson (check after the break for the full statement) that it has integrated the content it acquired from Frommer's and Wiley into its products including Google+ Local, that it has transferred ownership back to the founder and that it will continue licensing content from him. Why things took this circuitous route right back to the man who started it all back in 1957 is unknown and terms of the agreement were not disclosed, but we're sure fans of the budget travel how-tos are happy to see Frommer's keep going.
Welcome to The CITE -- a blog on Course materials, Innovation, and Technology in Education, created by Mark Nelson and now part of the Publications Department of the National Association of College Stores. CITE is a pun with multiple meanings - referring to cite as in citation, something people reference; site as in location, website, or place people go to; and sight as in foresight or looking ahead to what is coming. Comments, discussion, feedback and ideas are welcome.
TULSA, Okla. (AP) ? Citing the scope of a public health scare involving thousands of patients of an Oklahoma oral surgeon, the head of the state's dentistry board said Monday she wants prosecutors to consider pursuing criminal charges.
Nearly 1,000 of Dr. W. Scott Harrington's 7,000 patients have now been tested in Tulsa for hepatitis B and C as well as HIV, the virus that causes AIDS. About 400 people showed up at a clinic north of downtown Saturday, the first day the free tests were offered, and nearly 560 people showed up Monday.
Susan Rogers, the executive director of the Oklahoma Board of Dentistry, told The Associated Press that she talked with Tulsa County District Attorney Tim Harris on Monday to discuss whether Harrington is criminally liable.
"We're looking for the witnesses and individuals who can testify for us that this is what happened to me in (Harrington's) office," Rogers told AP.
The 17-count complaint filed last week by Rogers' office called Harrington a "menace to the public health." The complaint also said officials found rusty instruments, potentially contaminated drug vials and improper use of a machine designed to sterilize tools at Harrington's two Tulsa-area offices.
Harrington and his staff could face at least two felony charges, Rogers said, including practicing dentistry without a license and aiding or abetting another person who is violating the state's dental act. Rogers said each possible charge could carry a prison term of up to four years and a $10,000 fine.
"I did speak to the DA this morning and I've talked to other officials, and I can't comment on those conversations, but there's more to come," Rogers said.
A spokeswoman at the district attorney's office could not comment Monday because prosecutors haven't received any paperwork from the dentistry board. A message left Monday morning with Harrington's attorney in Tulsa was not immediately returned.
Harrington had been a dentist for 36 years before voluntarily giving up his license March 20. He faces an April 19 hearing at which he could have his certification revoked.
Letters have been sent to 7,000 patients, urging them to be screened for hepatitis B and C and the virus that causes AIDS. Those letters should arrive no later than about two weeks, Kaitlin Snider, spokeswoman for the Tulsa Health Department, said Monday.
"We are here for the long haul," Snider said. "We know we can't screen 7,000 patients in a day or even in a week."
Those who have been tested should receive their results within two weeks, she added.
According to the Oklahoma Dentistry Board's complaint, Harrington's practice had varying cleaning procedures for its equipment, needles were re-inserted in drug vials after their initial use and drug vials were used on multiple patients.
Also, dental assistants performed some tasks reserved to a licensed dentist, such as administering IV sedation. A device used to sterilize equipment hadn't undergone required monthly tests in at least six years.
"When this started, I had no idea it was going to be this bad or this broad," Rogers said Monday. "This one scared me."
The public alert began after a patient of Harrington's initially tested positive for HIV in a screening at a third-party provider. But more testing indicated that the patient was not positive for HIV, only hepatitis C, the Tulsa Health Department said Friday.
Court records show that Harrington was sued for medical malpractice in 1994, and the case was settled in 1995. He also was sued for negligence in 1997, which was settled out of court in the same year.
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Apr. 1, 2013 ? A team of international cancer researchers led by Dr. Mathieu Lupien at the Princess Margaret Cancer Centre, University Health Network, has identified the signalling pathway that is over-activated in estrogen receptor (ER)-positive breast cancer cells that are resistant to hormone therapies such as tamoxifen, aromatase inhibitors or fulvestrant.
Resistance to hormone therapy is reported in almost half of ER-positive breast cancer patients and no cure is currently available. The fact that the pathway, called Notch, is a drug target creates hope for a new therapy.
The findings, published online today in the Proceedings of the National Academy of Sciences, "provide a new therapeutic target against hormone therapy-resistant breast cancers and a companion test to identify tumours that would become resistant" says Dr. Lupien, a scientist at the Ontario Cancer Institute, the research arm of the cancer centre, and an Assistant Professor in the Department of Medial Biophysics, University of Toronto. He specializes in epigenetics of hormone-dependent cancers -- the study of non-genetic determinants of cellular identity that can also be altered to initiate or modify disease.
"In studying the epigenetics of hormone therapy resistance, we discovered that breast cancer cells behave like a chameleon. Indeed, as the chameleon changes its skin colour to camouflage itself and evade predators," says Dr. Lupien, "breast cancer cells change the appearance of their DNA through epigenetics to evade, in this case, hormone therapy." In so doing, hormone therapy-resistant breast cancer cells highlight regions of their DNA related to the Notch pathway.
At the molecular level, the research team characterized the epigenetic appearances of the DNA of drug-resistant and drug-responsive breast cancer cells. The team discovered that the Notch signaling pathway plays the predominant role in drug-resistant breast cancer cells even if cells remain positive for ER.
"This is a highly promising discovery that could rapidly translate in the clinic. Drugs against the Notch pathway are available." says Dr. Lupien. The key will be to test the efficacy of these drugs against hormone therapy resistance in breast cancer.
The research was funded by the National Cancer Institute, the American Cancer Society and the Ontario Institute for Cancer Research. Dr. Lupien's research is also supported by The Princess Margaret Cancer Foundation.
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The above story is reprinted from materials provided by University Health Network.
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Journal Reference:
Luca Magnani, Alexander Stoeck, Xiaoyang Zhang, Andr?s L?nczky, Anne C. Mirabella, Tian-Li Wang, Bal?zs Gyorffy, and Mathieu Lupien. Genome-wide reprogramming of the chromatin landscape underlies endocrine therapy resistance in breast cancer. Proceedings of the National Academy of Sciences, 2013; DOI: 10.1073/pnas.1219992110
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Technology ? is a queer thing. It brings you great gifts with one hand, and it stabs you in the back with the other. C. P. Snow, New York Times, 15 March 1971
One thing that beats me when I think about smartphones like Apple and Android, is the typical user?s reluctance to purchase Apps and equipment for it. Sure, after paying a few hundred bucks for the device (immediately or in contract rates), it is normal to be reluctant to pay even more for it. But on the other hand ? if you have already paid so much for it, why limit its uses when you have it?
Besides Apps, one of the best things you can purchase is ? in my opinion ? a waterproof casing. Some time ago I bought the necessary equipment to make my iPhone waterproof ? at least in principle. There are different cases that should make it waterproof, after looking around I tried Lifeproof(R).
As the rest of the site, this is without warranty. But due to the possible negative consequences, I repeat it explicitly: It worked for me (so far), but there are other reports on Amazon (seems bimodal, many love it, many hate it). I am guessing this is due to difference between actual and perfect-use failure rates when it comes to using the case. Here a mistake might cost you your device. Do this at your own risk!
I hope I never find out whether it survives when it is completely immersed in water. But so far, it survived more than one jogging trip through rain and snow ? while being strapped to my upper arm, exposed to the elements.
My jogging equipment: An iPhone 4 with a Lifeproof case and armband. The H20 earplugs are waterproof and are wound around the Buff headwear (worn around the neck while jogging). This keeps the motion of the earplug cable to a minimum.
But it?s not only good for jogging. The case allows me to use my iPhone to capture ideas in the rain. If I am walking to work, I can take it out and jot down ideas no matter whether it?s raining or not, and no matter whether I use an umbrella or not. It has more or less replaced my paper notebook, and in many ways, I prefer to capture most ideas digitally.
So, if you are using a digital device to capture your ideas, think about how you can make it more resistant and get more out of it.
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