Google Glass will reportedly be built in America, at least initially

That $1,500 price tag for Google Glass Explorer Edition? Perhaps it makes a bit more sense considering that US labor will be used to manufacturer it. According to unnamed sources cited by Financial Times, the first run of production-quality Glass headsets will be built in Santa Clara, California. The reason? A lot is riding on the quality of Glass, and it's likely that Google just wants to keep a close eye on every single prototype that leaves the lab. In fact, it's not exactly uncommon -- the outfit did the same for its ill-fated Nexus Q, and Apple is building some of its iMacs here in the states as well.

It's also important to note that the initial batch of Glass headsets won't be high yield, so there's little reason for Google to look overseas with so few units slated for production. Whether or not the lines in NorCal will continue to hum once these things hit critical mass remains to be seen, but it is interesting that Hon Hai Precision (read: Foxconn) will reportedly manage the facility that cranks 'em out.

Filed under: Wearables, Google

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Forty-six gene sequencing test for cancer patients in UK

Mar. 25, 2013 ? The first multi-gene DNA sequencing test that can help predict cancer patients' responses to treatment has been launched in the National Health Service (NHS), thanks to a partnership between scientists at the University of Oxford and Oxford University Hospitals NHS Trust.

The test uses the latest DNA sequencing techniques to detect mutations across 46 genes that may be driving cancer growth in patients with solid tumours. The presence of a mutation in a gene can potentially determine which treatment a patient should receive.

The researchers say the number of genes tested marks a step change in introducing next-generation DNA sequencing technology into the NHS, and heralds the arrival of genomic medicine with whole genome sequencing of patients just around the corner.

The many-gene sequencing test has been launched through the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), a collaboration between Oxford University Hospitals NHS Trust and Oxford University to accelerate healthcare innovation, and which has part-funded this initiative.

The BRC Molecular Diagnostics Centre carries out the test. The lab, based at Oxford University Hospitals, covers all cancer patients in the Thames Valley area. But the scientists are looking to scale this up into a truly national NHS service through the course of this year.

The new ?300 test could save significantly more in drug costs by getting patients on to the right treatments straightaway, reducing harm from side effects as well as the time lost before arriving at an effective treatment.

'We are the first to introduce a multi-gene diagnostic test for tumour profiling on the NHS using the latest DNA sequencing technology,' says Dr Jenny Taylor of the Wellcome Trust Centre for Human Genetics at Oxford University, who is programme director for Genomic Medicine at the NIHR Oxford BRC and was involved in the work. 'It's a significant step change in the way we do things. This new 46 gene test moves us away from conventional methods for sequencing of single genes, and marks a huge step towards more comprehensive genome sequencing in both infrastructure and in handling the data produced.'

Dr Anna Schuh, who heads the BRC Molecular Diagnostics Centre and is a consultant haematologist at Oxford University Hospitals, adds: 'Patients like the idea of a test that can predict and say up front whether they will respond to an otherwise toxic treatment. What the patient sees is no different from present. A biopsy is taken from the patient's tumour for genetic testing with a consultant talking through the results a few days later. It is part of the normal diagnostic process.'

Cancer is often described as a genetic disease, since the transition a cell goes through in becoming cancerous tends to be driven by changes to the cell's DNA. And increasingly, new cancer drugs depend on knowing whether a mutation in a single gene is present in a patient's cancer cells.

For example, a lung cancer patient may have a biopsy taken to check for changes in the EGFR gene. If there is a mutation, the patient may then be treated with a drug that works as an EGFR inhibitor. If there is no mutation, such drugs won't work and the patient would get a different drug that would be more effective for them. Knowing the presence or absence of mutations in a certain gene can choose the treatment path for that patient.

The NHS can currently test for mutations in 2 or 3 genes -- genes called BRAF, EGFR or KRAS -- using older sequencing technology that has been around for decades. Efforts are being made to look at increasing the number of cancer genes sequenced to nine as standard.

The Oxford scientists are the first to make such multi-gene tests possible in the NHS using the latest DNA sequencing techniques. The NHS service they have launched looks for mutations in 46 genes, and they are now working towards verifying the use of a test involving 150 genes.

Having a diagnostic test or 'panel' that can screen for mutations in multiple genes at once will be important for access to all the new cancer drugs that are coming along.

'It will be very difficult to manage in NHS diagnostic labs without gene panels,' explains Dr Schuh. 'Currently, new cancer drugs tend to get approved alongside a diagnostic test specific to that drug which can determine which patients will benefit. But as more and more drugs like this come along, we can't possibly run all the many different separate tests this could mean. We need one test for a range of drugs.'

Dr Taylor adds: 'We wanted a test that would use the latest DNA sequencing techniques to detect a wide range of mutations in a wide range of genes. A test that would be able to cover more cancers and more treatments, all for a similar cost to conventional methods.'

The test is run on a next generation sequencing platform from Life Technologies Corporation, called the Ion Personal Genome Machine (PGM(TM)). The test and accompanying software have been substantially modified as requested by the Oxford team to fulfil diagnostic standards in their lab.

This work was co-funded by the Technology Strategy Board, the UK's innovation agency, through a grant to the NIHR Oxford BRC, Life Technologies Corporation, AstraZeneca, and Janssen Research & Development, LLC, one of the Janssen Pharmaceutical Companies.

As part of the test development, the Oxford team looked to improve the initial sample preparation in the lab, and to provide the software and infrastructure support to handle and analyse the amount of information involved. Most importantly, the Oxford group has carried out tests and comparisons to verify the robustness of the technique with cancer biopsies direct from patients.

The team compared the new 46 gene test against conventional techniques for 80 consecutive cancer biopsies in the hospital lab's workflow.

The next-generation DNA sequencing method detected all the mutations the conventional method did; it detected new mutations the conventional method didn't; and detected mutations present at much lower levels in the samples. The time taken for the 46 gene test also fitted into the standard turnaround time for samples at the lab.

There is definite benefit in screening some of the 46 genes included in the test; there is probable or likely clinical benefit in screening some of the others; mutations in further genes might be important in some cancers but not others; and the other genes, we don't know as yet. But having this information means researchers can investigate whether a mutation has biological significance.

'We can keep data, bank it and link it with anonymised clinical data on patients' cancers for future research,' explains Dr Schuh.

The test looks for mutations in 'hotspot' regions of each gene -- areas where mutations are more likely to occur. This does mean the test may miss up to 5% of mutations, as they can occur elsewhere, but this is still significantly better than the 'false negative' rate using current methods.

It can also detect mutations present in only 5% of the tumour cells present in a sample. This is much lower than is possible currently, and is important in being able to capture information from cells present in only small numbers in a tumour, but which are still important in driving cancer growth.

Having shown that it is possible to introduce the 46 gene test as an NHS service, the researchers are now moving on to investigate the potential of a test that will sequence 150 genes. The team will use the test first of all with 500 existing samples from patients taking part in cancer clinical trials to be able to compare the results retrospectively with information from the trials. They will then use the test with 1000 new cancer biopsies to better understand how the extra information could be used in guiding treatments for patients and their outcomes.

Dr Schuh says: '"Panel" tests have significant potential while we wait for the cost of sequencing whole patient genomes to come down. Even then, panel tests may be with us for some time. After whole genome sequencing does come into use, it may be that panel tests are used first with patients' biopsies, with only those whose panel test shows no result having their entire DNA sequenced to look for rarer genetic changes.'

Lord Howe, Health Minister, said: 'We want to be among the best countries in the world at treating cancer and know that better tailored care for patients could potentially save lives.

'Health research like this is incredibly important and I'm delighted we could support the work of researchers in Oxford through the National Institute for Health Research Biomedical Research Centre.

'By rapidly translating findings from genetics research into real benefits for patients, their work will make sure that patients get the right treatments straight away, reduce potential side effects and also help us use NHS funds more effectively.'

The 46-gene panel is based on Ion AmpliSeq(TM) chemistry from Life Technologies Corporation. The test requires a very small amount of DNA (5 nanograms), an advantage when working with clinical samples that are typically limited in quantity.

The Ion Personal Genome Machine (PGM(TM) and Ion AmpliSeq(TM) are for Research Use Only, not intended for use in diagnostic procedures. Life Technologies intends to pursue CE-IVD designation for the PGM.

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Blake Shelton: Usher is a 'thorn in my side' on 'The Voice'

By Susan C. Young, TODAY contributor

Mark Seliger / NBC

Blake Shelton and new "Voice" coach Usher.

Blake Shelton says he?s not going to BS? ? ?The Voice? is going to be different when it comes back Monday night.

Gone are fellow coaches Cee Lo Green and Christina Aguilera. Their revolving red thrones will now be occupied by one-name wonders Shakira and Usher.

?It?s different with different personalities and a different chemistry,? Shelton shared at NBC's party at the TV Critic's winter press tour.

For one thing, he and fellow returning coach Adam Levine will be competing with smooth operator Usher and international superstar Shakira for the best competitors on the ?The Voice.?

Right away, he knew Usher would be a fierce competitor.

?This is the guy who found Justin Bieber,? Shelton said. ?That's what we are trying to do on this show, and he?s already done it.?

The country superstar knew a lot about Usher, but less about Shakira before the show started.

?The most intimidating thing came later. I had heard of Shakira, but one day I Googled her and Wikipediaed her,? Shelton said. ?And I saw where she had sold over a 100 million records and I was like, ?What the (expletive)?!???

He said that?s when he and Levine looked at each other and said, ?Hey, we?ve been worrying about the wrong person.?

The pre-voting shows have already been recorded, and although Shelton has won the last two battles with his team representative, he said he often gets shut down when he and other judges turn for the same contestant ? and have to woo the singer to their respective teams.

?The thorn in my side many times was Usher,? Shelton said. ?Adam always takes artists away from me and I?m used to that. But when Usher would turn around, especially if it was a girl, they would just melt when they saw that guy. So yeah, he was a problem.?

Not that it was so easy with Shakira, though.

?This is a girl who knows how to affect an audience, and she does it worldwide, ? Shelton said. ?I?m excited when I leave Oklahoma and somebody knows who I am.?

But does he engage in a little nose rubbing when it comes to his past wins?

?I don?t mention it unless I?m around Adam, knowing how competitive he is and what a baby he can be,? Shelton said with an impish grin.

For fans eager to watch how well the new judges mesh with the vets, there will be a spectacular joint performance.

?I?m not going to say which song because somebody will be bitching at me,? Shelton said. ?I will say the only thing that compares to it was the first season when we did Cee Lo?s ?Crazy.? I felt we were truly a band.?

"The Voice" airs Mondays and Tuesdays at 8 p.m. on NBC.

How do you think the new group of coaches will do this season? Tell us on our Facebook page!

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Why Coolidge Matters, With Charles C. Johnson (Powerlineblog)

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GOP's 'no' on Medicaid becomes "Let's make a deal'

JEFFERSON CITY, Mo. (AP) ? Given the choice of whether to expand Medicaid under President Barack Obama's health care law, many Republican governors and lawmakers initially responded with an emphatic "no."

Now they are increasingly hedging their objections.

A new "no, but ..." approach is spreading among GOP states in which officials are still publicly condemning the Democratic president's Medicaid expansion yet floating alternatives that could provide health coverage to millions of low-income adults while potentially tapping into billions of federal dollars that are to start flowing in 2014.

The Medicaid health care program for poor, which is jointly funded by the federal and state governments, already covers about one in five people in the U.S. Expanding it was the way Obama envisioned covering many more low-income workers who don't have insurance. The new Republican alternatives being proposed in states generally would go part of the way, but cover fewer people than Obama's plan, guarantee less financial help or rely more on private insurers.

But so far, many of the Republican ideas are still more wistful than substantive. It's uncertain whether they will actually pass. And even if they do, there's no guarantee Obama's administration will allow states to deviate too greatly from the parameters of the Affordable Care Act while still reaping its lucrative funding. Yet a recent signal from federal officials that Arkansas might be able to use Medicaid money to buy private insurance policies has encouraged Republicans to try alternatives.

The GOP proposals could lead to another health care showdown between the White House and states, leaving millions of Americans who lack insurance waiting longer for resolution. Officials in about 30 states that are home to more than 25 million uninsured residents remain either defiant or undecided about implementing Obama's Medicaid expansion, according to an Associated Press survey.

Supporters of the Medicaid expansion have built coalitions of hospitals, businesses groups, religious leaders and advocates for the poor to try to persuade reluctant Republicans of the economic and moral merits of Obama's health care plan. But some Republicans believe the pressure ultimately will fall on Obama to accept their alternatives if he wants to avoid a patchwork system for his signature accomplishment.

"If the Obama administration is serious about innovative ways to bring down the cost of health care, it's going to cooperate with conservative ideas rather than continue down its one-size-fits-all, far-left-wing ideological path," said Missouri Rep. Jay Barnes, a Republican from Jefferson City.

A House committee led by Barnes already has defeated Obama's version of Medicaid expansion. It is to hear public testimony Monday on his "market-based Medicaid" alternative that would award health care contracts to competing private insurers and provide cash incentives to patients who hold down their health-care costs. His proposal would contain costs by covering fewer children than Medicaid now does and adding fewer adults than Obama's plan envisions.

Committees in Florida's Republican-led Legislature also have rejected a Medicaid expansion for roughly 1 million of the state's poorest residents, even though it is backed by GOP Gov. Rick Scott. Now Republican Sen. Joe Negron is pursuing an alternative that would use federal funds to provide vouchers for low-income residents to buy private policies. Negron said he still doesn't believe expanding Medicaid is the right decision, but he wants to help Florida residents get health coverage.

"We don't want to do it the Washington way. We want to do it the Florida way," Negron said.

Republican Ohio Gov. John Kasich also has been in discussions with the Obama administration about providing subsidized insurance instead of full Medicaid coverage for more adults. Republican governors in Texas, Nebraska and Indiana want the federal government to award Medicaid money as block grants to states.

"It's a two-step for many of these Republican governors. When they look at the numbers they want to do it, but they want to distance themselves from Obamacare at the same time," said Drew Altman, president of the Kaiser Family Foundation, a nonprofit that analyzes health care policies.

That might be fine with the Obama administration.

"There actually is quite a bit of flexibility on how they can approach this, and the federal government has indicated they want to get to 'yes' " said Joan Alker, co-executive director of Georgetown University's Center for Children and Families in Washington, D.C.

As originally enacted, the Affordable Care Act required states to expand Medicaid to adults earning up to 138 percent of the federal poverty level, about $32,500 annually for a family of four. A Supreme Court decision last summer made the expansion optional for states but kept in place a powerful financial incentive. The federal government will fully fund the expansion for the first three years, with the states' share gradually increasing to 10 percent by 2020.

Health and Human Services Secretary Kathleen Sebelius said in December that getting full funding will still require a full expansion. Yet some Republicans in Missouri, South Dakota and elsewhere claim to see room for compromise.

LaTonya Jenkins, a 51-year-old laid off teacher's aide who lives in temporary housing for the homeless in Kansas City, recently enrolled in Medicaid but could lose coverage if her part-time job pushes her income over Missouri's strict eligibility limits. She recently traveled to Missouri Capitol to urge lawmakers to expand Medicaid.

"If they don't, and they cut it out, then what are we to do? We'll be lost," said a tearful Jenkins, who has diabetes and cares for her grandson. "I'll be sicker than ever and back in the hospital."

___

Associated Press writer Kelli Kennedy contributed to this report from Miami.

___

Follow David A. Lieb at: http://www.twitter.com/DavidALieb

Source: http://news.yahoo.com/gops-no-medicaid-becomes-lets-deal-161303765.html

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The Weekly Roundup for 03.18.2013

You might say the week is never really done in consumer technology news. Your workweek, however, hopefully draws to a close at some point. This is the Weekly Roundup on Engadget, a quick peek back at the top headlines for the past seven days -- all handpicked by the editors here at the site. Click on through the break, and enjoy.

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Source: http://www.engadget.com/2013/03/24/the-weekly-roundup-for-03-18-2013/

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Nurses provide care comparable to that of doctors for resolving health problems of low complexity

Public release date: 21-Mar-2013
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Contact: Amy Molnar
sciencenewsroom@wiley.com
Wiley

A new study has found that Spanish nurses trained specifically to resolve acute health problems of low complexity provide care of comparable quality to that of general practitioners. Published early online in the Journal of Advanced Nursing, the findings suggest that nurses may be able to take on some of the care generally provided by physicians.

Mireia Fbregas, MD, of the Institut Catal de la Salut, in Barcelona, Spain, and her colleagues randomized 1461 adult patients who requested same day appointments to see either nurses trained to respond to problems with low complexity or to see general practitioners. The study was conducted in 38 general practices in Catalonia, Spain, and 142 general practitioners and 155 nurses participated. The investigators measured how well patients' symptoms resolved and how satisfied patients were two weeks after the visit.

The investigators found that nurses successfully solved 86.3% of the cases. The health problem that nurses solved with greatest ease was burns, followed by injuries and acute diarrhea. Nurses were less successful at resolving low back pain, acute mild upper respiratory symptoms, and urinary discomfort. "This lower resolution could be explained by the fact that these problems require more complex physical examinations that are not usual in a nurse's daily work," said Dr. Fbregas. Patients who saw nurses were equally satisfied with their visit as those who saw doctors. When patients were asked about their preferences regarding which professional they would like to visit if a similar health problem arose again, more than 40% of patients in each group expressed indifference.

"This study could help to reduce resistance to change in both physicians and nurses, as well as in the general population, generating confidence in the care provided by nurses," said Dr. Fbregas. She and her co-authors noted that having nurses solve acute diseases of low complexity could help improve overall health care efficiency.

###

URL Upon publication: http://doi.wiley.com/10.1111/jan.12120

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 21-Mar-2013
[ | E-mail | Share ]

Contact: Amy Molnar
sciencenewsroom@wiley.com
Wiley

A new study has found that Spanish nurses trained specifically to resolve acute health problems of low complexity provide care of comparable quality to that of general practitioners. Published early online in the Journal of Advanced Nursing, the findings suggest that nurses may be able to take on some of the care generally provided by physicians.

Mireia Fbregas, MD, of the Institut Catal de la Salut, in Barcelona, Spain, and her colleagues randomized 1461 adult patients who requested same day appointments to see either nurses trained to respond to problems with low complexity or to see general practitioners. The study was conducted in 38 general practices in Catalonia, Spain, and 142 general practitioners and 155 nurses participated. The investigators measured how well patients' symptoms resolved and how satisfied patients were two weeks after the visit.

The investigators found that nurses successfully solved 86.3% of the cases. The health problem that nurses solved with greatest ease was burns, followed by injuries and acute diarrhea. Nurses were less successful at resolving low back pain, acute mild upper respiratory symptoms, and urinary discomfort. "This lower resolution could be explained by the fact that these problems require more complex physical examinations that are not usual in a nurse's daily work," said Dr. Fbregas. Patients who saw nurses were equally satisfied with their visit as those who saw doctors. When patients were asked about their preferences regarding which professional they would like to visit if a similar health problem arose again, more than 40% of patients in each group expressed indifference.

"This study could help to reduce resistance to change in both physicians and nurses, as well as in the general population, generating confidence in the care provided by nurses," said Dr. Fbregas. She and her co-authors noted that having nurses solve acute diseases of low complexity could help improve overall health care efficiency.

###

URL Upon publication: http://doi.wiley.com/10.1111/jan.12120

---

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-03/w-npc031913.php

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Sister of comedian wins Democratic primary for South Carolina House seat: CNN (reuters)

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Influential pediatricians group backs gay marriage

CHICAGO (AP) ? The nation's most influential pediatrician's group has endorsed gay marriage, saying a stable relationship between parents regardless of sexual orientation contributes to a child's health and well-being.

The American Academy of Pediatrics' new policy, published online Thursday, cites research showing that the parents' sexual orientation has no effect on a child's development. Kids fare just as well in gay or straight families when they are nurturing and financially and emotionally stable, the academy says.

The academy believes that a two-parent marriage is best equipped to provide that kind of environment. Their policy says that if a child has two gay parents who choose to marry, "it is in the best interests of their children that legal and social institutions allow and support them to do so."

The policy cites reports indicating that almost 2 million U.S. children are being raised by gay parents, many of them in states that don't allow gays to marry.

The academy announced its position Thursday. Officials with the group said they wanted to make the academy's views known before two gay marriage cases are considered by the U.S. Supreme Court next week.

"We wanted that policy statement available for the justices to review," said Dr. Thomas McInerney, the academy's president and a pediatrician in Rochester, N.Y.

The pediatricians' stance is not surprising. They previously joined other national groups including the American Medical Association in supporting one of the Supreme Court cases, which contends the Defense of Marriage Act is unconstitutional. The academy also previously supported adoption by gay parents.

The academy's statement notes that several other national health groups have supported gay marriage. Those are the American Academy of Family Physicians, the American Psychiatric Association, the American Psychological Association and the American College of Nursing.

Dr. Ben Siegel, a Boston pediatrician and chairman of an academy committee that developed the new policy, said its focus is on "nurturing children. We want what's best for children."

___

Online:

Academy: http://www.aap.org

___

AP Medical Writer Lindsey Tanner can be reached at http://www.twitter.com/LindseyTanner

Associated Press

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News ratings plummet with time change, longer days

NEW YORK (AP) ? Despite a busy week with the selection of a new pope, the ABC, CBS and NBC evening newscasts collectively had 11 percent fewer viewers than the week before ? and a glance outside the window reveals the primary reason why.

The simple act of moving the clock ahead one hour for daylight saving time is costly for the broadcasts, since the hour that turns from darkness to light happens to be the hour in which they are shown in most of the country.

It's not just a one-week phenomenon. The newscasts will have to deal with smaller audiences until the clocks are pushed back in the fall.

"What it shows is that a large proportion of the people that watch the news are not watching because they watch the news," said news consultant Andrew Tyndall. "They're watching it because they happen to be home when the news is on."

Both NBC's "Nightly News" and ABC's "World News" lost a million viewers from week to week, the Nielsen Co. said. The "CBS Evening News" lost 600,000. That's a total of 2.6 million, or a little more than the entire audience for the NBC sitcom "Community" last week.

While the situation isn't unusual, each newscast lost more viewers in the week-to-week comparison than they did between 2012 and 2011.

"Nightly News" had an average of 8.1 million viewers last week (5.4, 11). ABC was second with 7.2 million (4.9, 10) and CBS had 6.4 million viewers (4.3, 9).

In prime time last week, an estimated 10.4 million people watched Sean Lowe propose to Catherine Giudici in the finale of season 17 of "The Bachelor." That's up 13 percent over the audience that watched last year's finale, with an even bigger increase among the 18-to-49-year-old viewers that ABC considers most important for its advertisers.

Meanwhile, PBS reported that the third season of "Downton Abbey," which concluded last month, represented the most-watched drama on the public broadcaster in all time.

CBS averaged 8.6 million viewers (5.5 rating, 9 share) in prime-time to win the week. Fox had 6 million viewers (3.6, 6), ABC had 5.8 million (3.8, 6), NBC had 3.8 million (2.5, 4), the CW had 1.19 million and ION Television had 1.15 million (both 0.8, 1)

Among the Spanish-language networks, Univision led with a 3.3 million viewer average (1.8, 3), Telemundo had 1.3 million (0.7, 1), UniMas had 480,000 (0.3, 0), Estrella had 190,000 and Azteca 90,000 (both 0.1, 0)

A ratings point represents 1,147,000 households, or 1 percent of the nation's estimated 114.7 million TV homes. The share is the percentage of in-use televisions tuned to a given show.

For the week of March 11-17, the top 10 shows, their networks and viewerships: "The Big Bang Theory," CBS, 15.9 million; "Person of Interest," CBS, 14.34 million; "American Idol" (Wednesday), Fox, 13.44 million; "NCIS," CBS, 13.18 million; "Two and a Half Men," CBS, 12.18 million; "NCIS: Los Angeles," CBS, 11.95 million; "American Idol" (Thursday), Fox, 11.93 million; "Elementary," CBS, 11.33 million; "The Bible," History, 10.87 million; "The Walking Dead," AMC, 10.84 million.

___

ABC is owned by The Walt Disney Co. CBS is owned by CBS Corp. CW is a joint venture of Warner Bros. Entertainment and CBS Corp. Fox and My Network TV are units of News Corp. NBC and Telemundo are owned by Comcast Corp. ION Television is owned by ION Media Networks. TeleFutura is a division of Univision. Azteca America is a wholly owned subsidiary of TV Azteca S.A. de C.V.

___

Online:

http://www.nielsen.com

Source: http://news.yahoo.com/news-ratings-plummet-time-change-longer-days-192205261.html

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Global rise in type 1 diabetes may be linked to reduced exposure to pathogens in early life

Mar. 19, 2013 ? Countries with lower mortality from infectious disease exhibit higher rates of type 1 diabetes, according to a new study by Dr. A. Abela and Professor S. Fava of the University of Malta. The findings, collating data from three major international studies and presented at the Society for Endocrinology annual conference in Harrogate UK, suggest that the as yet unexplained global rise in type 1 diabetes may be linked to reduced exposure to pathogens in early life.

Type 1 diabetes is caused when the immune system destroys the cells of the pancreas that release insulin, leaving the patient unable to control his own blood sugar. It is estimated to affect around half a million children worldwide, increasing in incidence by an estimated 3% every year. This increase is well documented and is linked to the developed world, but is so far unexplained -- various theories put forward include the 'hygiene hypothesis', which suggests that encounters between the developing immune system and micro-organisms such as bacteria and parasites are part of human evolution and may therefore protect against the development of auto-immunity.

The researchers investigated whether markers of infectious disease burden could be linked to the local incidence of type 1 diabetes. They used data from the World Health Organisation (WHO) DiaMond Project, WHO global burden of disease: 2004 update, and the Alexander Project, to correlate type 1 diabetes incidence by country with mortality from infectious disease and bacterial antibiotic susceptibility (which indicates antibiotic use and thus exposure to bacterial infection).

Type 1 diabetes rates were highest in countries with low mortality from infectious disease. This was true for total mortality from infectious disease (r=-0.35, p=0.008), as well as deaths caused specifically by diarrhea, respiratory disease, tuberculosis, and infections and parasitic disease (all p<0.05). They also found type 1 diabetes rates are significantly associated with the local susceptibility of the bacteria Streptococcus pneumoniae to all antibiotics studied.

This study suggests that there may be an association between type 1 diabetes rates and infectious disease burden. It is possible that the increasing global incidence of type 1 diabetes may be linked to lack of exposure to pathogens during early life. Whilst the data provide support for the hygiene hypothesis they do not prove it: the rise in type 1 diabetes rates is a complex problem and this study is of association only. Other potential contributing factors may show a similar geographical variation to infectious disease burden, as this is linked to the developed world. The authors are keen to use further studies to identify other environmental factors which may predispose to type 1 diabetes.

Study leader Professor Stephen Fava, Consultant in Diabetes and Endocrinology at Mater Dei Hospital, Malta & Associate Professor of Medicine at the University of Malta, said:

"The global rise in type 1 diabetes is an unexplained phenomenon. Many suggest that the exposure, or rather the lack of exposure, to infectious disease when young might be linked to the development of autoimmunity.

"Our data show that type 1 diabetes rates were highest in countries where markers of exposure to infectious disease were lowest. Incidence of type 1 diabetes was significantly linked to mortality from a variety of infectious diseases and to the local susceptibility of a common bacterium to antibiotics.

"These data provide support for the notion that the immune system can somehow become disordered and attack the body's own cells if it is not trained by regular exposure to micro-organisms -- the so called hygiene hypothesis. More research is needed to try to identify other environmental factors that may be linked to the continuing conundrum of rising type 1 diabetes rates."

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Journal Reference:

1. Alexia-Giovanna Abela, Stephen Fava. Association of the incidence of type 1 diabetes with markers of infection and antibiotic susceptibility at country level. Endocrine Abstracts, 2013; : 1 DOI: 10.1530/endoabs.31.P223

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/uvas5-Loy9c/130318203334.htm

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NASA sees remnants of Cyclone Tim fading near southeastern Queensland

Public release date: 18-Mar-2013
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Contact: Rob Gutro
Robert.j.gutro@nasa.gov
443-858-1779
NASA/Goddard Space Flight Center

Infrared satellite imagery tells the temperature of the cloud tops within a tropical cyclone as well as the sea surface temperatures around the storms. A recent infrared image from NASA's Aqua satellite showed very little strength in the remnants of ex-cyclone Tim offshore from southeastern Queensland.

The Atmospheric Infrared Sounder (AIRS) instrument aboard NASA's Aqua satellite captured an infrared image of Cyclone Tim on March 18 at 0355 UTC (March 17 at 11:55 p.m. EDT). The AIRS image showed that cloud top temperatures had warmed significantly since the previous day as the low pressure area continues to weaken. The coldest cloud top temperatures and strongest thunderstorms appeared in small area offshore from southeastern Queensland.

On March 18 at 1200 UTC (8 a.m. EDT/10 p.m. local time, Brisbane, Queensland, Australia), the remnants of ex-cyclone Tim was located near 19.1 south latitude and 151.7 east longitude, was located about 190 nautical miles (218.6 miles/ 352 km) northeast of Mackay. Tim's remnants were drifting west at 2 knots (2.3 mph/3.7 kph). The Australian Bureau of Meteorology (ABOM) noted that Tim's remnants are causing rough to very rough seas and moderate south to southeasterly swell. According to ABOM, wind gusts to 40 knots (46 mph/74 kph) are possible from Tim's remnants.

As a result of Tim's close proximity to the Queensland coast, several warnings were posted on March 18 at 2:15 p.m. EDT/U.S. (12:15 a.m. local time, Brisbane on Tuesday, March 19). A Gale Warning is in effect from Townsville to Bowen and from Bowen to Yeppoon, Strong Wind Warnings are in effect from Cardwell to Townsville and from Yeppoon to Double Island Point, including Hervey Bay. A Coastal Waters Wind Warning was also posted for Cardwell to Double Island Point, including Hervey Bay.

ABOM expects Tim's remnants to move in a west-northwest direction towards the Queensland coast over the next few days.

###

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 18-Mar-2013
[ | E-mail | Share ]

Contact: Rob Gutro
Robert.j.gutro@nasa.gov
443-858-1779
NASA/Goddard Space Flight Center

Infrared satellite imagery tells the temperature of the cloud tops within a tropical cyclone as well as the sea surface temperatures around the storms. A recent infrared image from NASA's Aqua satellite showed very little strength in the remnants of ex-cyclone Tim offshore from southeastern Queensland.

The Atmospheric Infrared Sounder (AIRS) instrument aboard NASA's Aqua satellite captured an infrared image of Cyclone Tim on March 18 at 0355 UTC (March 17 at 11:55 p.m. EDT). The AIRS image showed that cloud top temperatures had warmed significantly since the previous day as the low pressure area continues to weaken. The coldest cloud top temperatures and strongest thunderstorms appeared in small area offshore from southeastern Queensland.

On March 18 at 1200 UTC (8 a.m. EDT/10 p.m. local time, Brisbane, Queensland, Australia), the remnants of ex-cyclone Tim was located near 19.1 south latitude and 151.7 east longitude, was located about 190 nautical miles (218.6 miles/ 352 km) northeast of Mackay. Tim's remnants were drifting west at 2 knots (2.3 mph/3.7 kph). The Australian Bureau of Meteorology (ABOM) noted that Tim's remnants are causing rough to very rough seas and moderate south to southeasterly swell. According to ABOM, wind gusts to 40 knots (46 mph/74 kph) are possible from Tim's remnants.

As a result of Tim's close proximity to the Queensland coast, several warnings were posted on March 18 at 2:15 p.m. EDT/U.S. (12:15 a.m. local time, Brisbane on Tuesday, March 19). A Gale Warning is in effect from Townsville to Bowen and from Bowen to Yeppoon, Strong Wind Warnings are in effect from Cardwell to Townsville and from Yeppoon to Double Island Point, including Hervey Bay. A Coastal Waters Wind Warning was also posted for Cardwell to Double Island Point, including Hervey Bay.

ABOM expects Tim's remnants to move in a west-northwest direction towards the Queensland coast over the next few days.

###

---

[ | E-mail | Share ]

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-03/nsfc-nsr031813.php

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Major Nigeria airline halts flights over strike

LAGOS, Nigeria (AP) ? A major Nigerian airline says it has suspended its flights after failing to reach an agreement with striking workers.

Simon Tumba, a spokesman for Aero Contractors Co. of Nigeria Ltd., said Saturday the strike, which started Wednesday, has halted flights "temporarily."

Many foreign oil companies patronize Aero Contractors, which operates flights to major domestic destinations and neighboring Ghana. The company's website said it is working to restore flights "as quickly as possible."

Nigeria's aviation industry has faced a series of challenges over the past year.

One of its carriers was grounded last June after a crash that killed more than 160 people. It has been battling to win back flyers' confidence since it resumed operations two months ago. Another carrier collapsed last year amid allegations it hadn't paid staff for months.

Source: http://news.yahoo.com/major-nigeria-airline-halts-flights-over-strike-140713724.html

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College mourns pregnant Pa. coach killed in crash

This undated photo provided by Seton Hill University shows women's college lacrosse coach Kristina Quigley. A tour bus carrying the Seton Hill women's lacrosse team to a game went off the Pennsylvania Turnpike on Saturday, March 16, 2013, and crashed into a tree. Authorities said the accident killed the driver and Kristina Quigley, who was about six months pregnant, and sent others to the hospital. (AP Photo/Courtesy Seton Hill University)

This undated photo provided by Seton Hill University shows women's college lacrosse coach Kristina Quigley. A tour bus carrying the Seton Hill women's lacrosse team to a game went off the Pennsylvania Turnpike on Saturday, March 16, 2013, and crashed into a tree. Authorities said the accident killed the driver and Kristina Quigley, who was about six months pregnant, and sent others to the hospital. (AP Photo/Courtesy Seton Hill University)

Emergency and rescue crews respond to the scene of a tour bus crash on the Pennsylvania Turnpike on Saturday, March 16, 2013 near Carlisle, Pa. Authorities say the tour bus crashed on the freeway at mile marker 227 in central Pennsylvania, and serious injuries have been reported. Megan Silverstram of the Cumberland County public safety department says the crash in the eastbound lanes of the Pennsylvania Turnpike was reported just before 9 a.m. Saturday. She says there are reports of multiple injuries, including that some are serious. (AP Photo/The Sentinel, Jason Malmont ) MANDATORY CREDIT

UPDATES INFORMATION ON BUS CRASH - Members of the Cumberland County Coroners Office investigate the scene of a tour bus crash on the Pennsylvania Turnpike on Saturday, March 16, 2013 near Carlisle, Pa. Authorities say the tour bus crashed on the freeway at mile marker 227 in central Pennsylvania, and serious injuries have been reported. Lacrosse players from Seton Hill University and three coaches were among the 23 people aboard when the bus crashed at about 9 a.m., turnpike spokeswoman Renee Colborn said. It's not clear what caused the crash, but state police were investigating, said Megan Silverstram of the Cumberland County public safety department. (AP Photo/The Sentinel, Jason Malmont ) MANDATORY CREDIT

Emergency and rescue crews respond to the scene of a tour bus crash on the Pennsylvania Turnpike on Saturday, March 16, 2013 near Carlisle, Pa. Authorities say the tour bus crashed on the freeway at mile marker 227 in central Pennsylvania, and serious injuries have been reported. Megan Silverstram of the Cumberland County public safety department says the crash in the eastbound lanes of the Pennsylvania Turnpike was reported just before 9 a.m. Saturday. She says there are reports of multiple injuries, including that some are serious. (AP Photo/The Sentinel, Jason Malmont ) MANDATORY CREDIT

UPDATES INFORMATION ON BUS CRASH - Emergency and rescue crews respond to the scene of a tour bus crash on the Pennsylvania Turnpike on Saturday, March 16, 2013 near Carlisle, Pa. Authorities say the tour bus crashed on the freeway at mile marker 227 in central Pennsylvania, and serious injuries have been reported. Lacrosse players from Seton Hill University and three coaches were among the 23 people aboard when the bus crashed at about 9 a.m., turnpike spokeswoman Renee Colborn said. It's not clear what caused the crash, but state police were investigating, said Megan Silverstram of the Cumberland County public safety department. (AP Photo/The Sentinel, Jason Malmont ) MANDATORY

GREENSBURG, Pa. (AP) ? A small Catholic college outside Pittsburgh mourned the loss of a women's lacrosse coach who died along with her unborn child when the team's bus crashed on the way to a game, remembering her Sunday as warm, outgoing and a natural leader.

Team members and fans at a Seton Hill University baseball game observed a minute of silence for the two crash victims. With the players in the background on a cold day, students and other mourners visited a tribute set up in front of a lacrosse net next to the baseball field that featured bouquets of flowers, stuffed animals, a lacrosse stick, a whistle and a candle sat in front of a team photo and signs reading "In memoriam - Kristina Quigley - Forever a Griffin."

Players and coaches from Seton Hill were among 23 people aboard when the bus crashed into a tree Saturday morning on the Pennsylvania Turnpike outside Harrisburg. The team was headed to an afternoon game at Millersville University, about 50 miles from the crash site in central Pennsylvania. Police are investigating the cause.

Head coach Quigley, 30, of Greensburg, died of her injuries at a hospital, Cumberland County authorities said. Quigley was about six months pregnant, and her unborn son didn't survive. The bus driver, Anthony Guaetta, 61, of Johnstown, died at the scene.

Saturday's game and a Sunday home game were canceled after the crash, and Seton Hill, a Catholic liberal arts school of about 2,500 students, said a memorial Mass was planned for Sunday night on campus. The school is also offering grief counseling to students.

Duquesne University women's lacrosse coach Mike Scerbo remembered Quigley as a warm, outgoing person who immediately impressed him when he hired her to be an assistant during the 2008 season. Quigley, a Duquesne alum, spent just one season under Scerbo before moving to South Carolina to start Erskine College's NCAA Division II program.

"In that time, I really saw how much passion she had to be a coach, and how much she enjoyed working with the kids," Scerbo said. "She was a teacher, and she wanted to help kids grow and learn, not just about the sport, but about life."

She spent three years at Erskine before taking the top job at Seton Hill for the 2012 season. She stayed in touch with Scerbo, often seeking his guidance and showing up at the Duquesne alumni game.

"She was a very happy person, very passionate about life, about her players, about her job and most importantly about her family," Scerbo said.

Quigley, a native of Baltimore, was married and had a young son, Gavin, the school said.

Two victims flown to Penn State Hershey Medical Center remained there Sunday, and no information was released about them. A woman injured in the crash was discharged Sunday afternoon from another hospital. All others aboard the bus were taken to hospitals as a precaution, but almost all were treated and released.

Police couldn't immediately say what had caused the crash. The front side of the bus, which was towed from the scene Saturday night, was shorn away, and the vehicle came to rest upright about 70 yards from the highway at the bottom of a grassy slope.

The bus operator, Mlaker Charter & Tours, of Davidsville, Pa., is up to date on its inspections, which include bus and driver safety checks, said Jennifer Kocher, a spokeswoman for the state Public Utility Commission, which regulates bus companies.

The agency's motor safety inspectors could think of no accidents or violations involving the company that would raise a red flag, she said, though complete safety records were not available Saturday.

On Tuesday, another bus carrying college lacrosse players from a Vermont team was hit by a sports car that spun out of control on a wet highway in upstate New York, sending the bus toppling onto its side, police said. One person in the car died.

___

Todt reported from Philadelphia.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-03-17-Lacrosse%20Team-Bus%20Crash/id-41b223facc72466e9f20f5e447abb078

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Google acquires neural network startup that may help it hone speech recognition and more

Mountain View has just picked up some experts on deep neural networks with their acquisition of DNNresearch, which was founded last year by University of Toronto professor Geoffrey Hinton and graduate students Alex Krizhevsky and Ilya Sutskever. The group is being brought into the fold after developing a solution that vastly improves object recognition. As a whole, advances in neural nets could lead to the development of improved computer vision, language understanding and speech recognition systems. We reckon that Page and Co. have a few projects in mind that would benefit from such things. Both students will be transitioning to Google, while Hinton will split his attention between teaching and working with the search giant.

Filed under: Misc, Internet, Google

Comments

Via: TechCrunch

Source: University of Toronto

Source: http://www.engadget.com/2013/03/13/google-acquires-neural-network-startup-dnnresearch/

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Obama reacts to new pope (CNN)

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The Eating Disorder Pro Podcast ? Female Athlete Triad Syndrome ...

Join us on Tuesday March 19?at 7 pm EST as we talk with Dr. Kelly Austin about Female Athlete Triad Syndrome! We?ll be taking your questions LIVE ?at?646-378-0494. Tune in HERE!

About Dr. Austin

Dr. Kelly Austin received her degree in naturopathic medicine from the Canadian College of Naturopathic Medicine in 2004. She practiced in Canada for several years before relocating to San Diego. She has spent the majority of her career working in corporate settings helping the employees establish a healthy lifestyle, as well as lecturing for government agencies. She is currently the clinic director of two practices in San Diego, California.

Dr. Austin has a special focus on hormone (endocrine) metabolism and lifestyle medicine. She has a passion for teaching patients how all the hormones work together to ensure optimal health. Dr. Austin?teaches her patients lifestyle changes that will stick for life and reverse and prevent chronic illness. Through addressing the underlying causes, she works with her patients to provide them with the most up?to date research.

Dr. Austin?s special interests also include clinical nutrition, eating disorders, weight management, and mental health. She is a DAN! Doctor and sees many patients with Autism and Down Syndrome. She is also a certified fitness instructor helping many people achieve their health & fitness goals.

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Medical Advice Disclaimer: The information included on this site is for educational purposes only. It is not intended nor implied to be a substitute for professional medical advice. The reader should always consult his or her healthcare provider to determine the appropriateness of the information for their own situation or if they have any questions regarding a medical condition or treatment plan. Reading the information on this website does not create a physician-patient relationship.

Tags: Dr. Kelly Austin, eating disorder podcast, Eating Disorder Treatment Cincinnati, Eating Disorders, female athlete triad syndrome

This entry was posted on Wednesday, March 13th, 2013 at 8:51 am and is filed under Eating Disorder Pro - The Podcast. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.

Source: http://www.eatingdisorderpro.com/2013/03/13/the-eating-disorder-pro-podcast-female-athlete-triad-syndrome-dr-kelly-austin/

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Essential No-Nonsense Web Hosting Advice And Guidance ...

Author: Greg James | Total views: 118 Comments: 0
Word Count: 901 Date: Tue, 12 Mar 2013 5:05 PM

You may feel concerned when you see the charges you receive monthly from the company that hosts your website. There are web hosts out there that are both good and affordable. You can use the tips you are about to read to find the excellent web hosting you know you deserve.

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Call or email customer support of your web host company before making decisions. You have to know that they will help you in a pleasant, professional way. Knowing what kind of service they provide will save you much time and effort down the road.

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Call or email customer support of your web host company before making decisions. Evaluate whether their response was courteous, helpful and professional. Knowing that you can count on your host's service department is crucial to having a satisfying relationship with them.

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If you want to draw more traffic with your site, choose a web host with a solid SEO feature. This kind of feature means your site will be registered with search engines. If traffic is of utmost importance to you, register the site on your own so that you can add in detailed descriptions of your site to help increase your rankings.

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by: Mike Christie on: Sat, 29 Sep 2012

2: Why You Need To Build Multiple Streams of Income For Yourself

Being an entrepreneur and earning multiple streams of income is a dream that many have, but in reality it does take some initial hard work to achieve this. Earning multiple streams of income is the wave of the future, and here are some tips and advice for you when you are looking for ways in which to do this for yourself.

by: Michel Maling on: Sat, 29 Sep 2012

3: What is Cyber Marketing And Why It Is So Important For The Success Of Your Website

Cyber marketing has now become an indispensable segment of e-commerce as well as the internet and World Wide Web related topics. Cyber marketing simply refers to a technique of attracting potential customers by advertising your products or services through such means as websites, emails, and banners.

by: WJaegel on: Tue, 18 Dec 2007

4: Article Marketing Strategy: Putting Together a "Class Schedule" For Your Article Topics

Businesses go to so much trouble when there is one sure-fire, simple, very inexpensive way to attract new clients to a business: Teach a free class. That is what article marketing is like. Your articles are just like free classes. You teach your target readers something helpful in your article. Your resource box then says, "If you enjoyed this article you can visit my website and apply what you have learned."

by: Steve Shaw on: Sat, 23 Apr 2011

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Source: http://www.content4reprint.com/internet-marketing/essential-no-nonsense-web-hosting-advice-and-guidance.htm

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